The theme of the Cultural Missions concerning to educational topic, is one of the microhistory bastions of Santiago Yolomécatl, Oaxaca. Santiago Augusto Sierra, in his book The Cultural Missions, SEP Seventies collection, mentions that in 1924, during the government of President Álvaro Obregón, and Jose Vasconcelos as head of the newly created Ministry of Public Education, start the creation of the “Cultural Missions”, one of them came to Santiago Yolomécatl, so we can say that the community Yolomécatl, is the cradle of education postrevolutionary Mexico with Vasconcelista project literacy, teaching arts and trades to the people of Mexico through the Cultural Missions. The article focuses precisely the relevance of the Cultural Missions in the Oaxacan Mixteca, emphasizing the installed in Santiago Yolomécatl, Oaxaca in 1925. For shaping the information and statements contained, turned to oral history, recovered through numerous interviews with key informants in the community. On the other hand, was a research on rescue of old photography as a means to retrieve valuable information from the time it is addressed. Several photographs denote how was this process of Cultural Missions in the Oaxacan Mixteca.