The corn processing industry has increased its product output, resulting in a considerable increase in wastewater due to the treatment called nixtamalization. The extract is discharged directly into the sewer system, and there is significant evidence of its contribution to environmental pollution. The aim of this paper is to propose a membrane process for the treatment of these wastewaters, in order to reduce their pollutant load in terms of polyphenols, carbohydrates, turbidity, total soluble solids (TSS), total solids content (TSC), pH, calcium, electrical conductivity and total organic carbon (TOC). The wastewaters had a high content of polyphenols (1,190.74 mggallic acid∙liter-1), turbidity (538.09 NTU), TSC (1.34 %), pH (13.48), electrical conductivity (2,424.00 μS∙cm-1), calcium (1,078.3 mg·liter-1), TOC (2,984.10 mg·liter-1) and low content of carbohydrates (3.47 mg·mL-1) and TSS (1.53 ºBrix). The wastewaters were subjected to a microfiltration separation process using a hollow fiber membrane (pore size: 0.2 μm). The viability of the process was analyzed in terms of productivity (709 kg·m-2·h-1 permeate flux), fouling index (22.68 %) and washing efficiency (99.82 %) by enzymatic methods. The membrane showed high retention in turbidity (72.76 %), followed by TSC (23.74 %), electrical conductivity (21.75 %), TSS (15.14 %), carbohydrates (14.69 %) and calcium (11.36 %). Finally, a significant decrease in organic concentration, in terms of TOC, was achieved in the effluent.